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KMID : 1161520160200020077
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Animal Cells and Systems
2016 Volume.20 No. 2 p.77 ~ p.85
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Resveratrol suppresses the epithelial-to-mesenchymal transition in PC-3 cells by down-regulating the PI3K/AKT signaling pathway
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Wang Zhi
Wu Longxiang
Tong Shiyu
Hu Xiheng
Zu Xiongbing
Li Yuan
He Wei
Liu Longfei
Chen Minfeng
Qi Lin
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Abstract
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Resveratrol possesses a wide spectrum of pharmacological properties and has been an ideal alternative drug for the treatment of different cancers, including prostate cancer. However, the mechanisms by which resveratrol inhibits the growth of prostate cancer are still not fully elucidated. To understand the effect of resveratrol on the apoptosis and the epithelial-to-mesenchymal transition (EMT) of prostate cancer as well as its related mechanism, we investigated the potential use of resveratrol in PC-3 prostate cancer cells in vitro using real-time PCR, fluorescence-activated cell sorting, Western blotting, etc. Resveratrol suppresses the PC-3 prostate cancer cell growth and induces apoptosis. Resveratrol also influences the expression of EMT-related proteins (increased E-cadherin and decreased Vimentin expression). Finally, resveratrol also suppressed Akt phosphorylation in PC-3 cells. This study indicates that resveratrol may be a potential anti-cancer treatment for prostate cancer; moreover, it provides new evidence that resveratrol suppresses prostate cancer growth and metastasis.
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KEYWORD
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Resveratrol, epithelial-to-mesenchymal transition, prostate cancer, apoptosis, PI3K/Akt pathway
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